Experiment 2: 4-Bromobenzophenone by the Friedel-Craft reaction. Objectives
To bring in an acyl group in an aromatic ring by accomplishing an electrophilic replacement To prepare 4-Bromobenzophenone by Friedel Crafts reaction
Friedel-Crafts reaction is known as a reaction to add a substituents to an aromatic ring. That involves an electrophilic alternative. Friedel-Crafts acylation is theВ acylationВ of aromatic bands with anВ acyl chlorideВ using a strongВ Lewis acidВ catalyst. Friedel-Crafts acylation is also conceivable withВ acid anhydrides. Reaction conditions are similar to the Friedel-Crafts alkylation mentioned above. (1)
BenzophenoneВ is theВ organic compoundВ with the formulation (C6H5)2CO, generally abbreviatedВ Ph2CO. Benzophenone is a widespread building block in organic biochemistry, being the parent diarylketone. (2) 4-Bromobenzophenone with the formula of (C13H9BrO) is definitely obtained by reaction between bromobenzene and benzoyl chloride under Friedel-Crafts reaction. The development of an acyl group in to an aromatic ring can be accomplished by an electrophilic replacement by the acylium ion produced by the response between a great acyl halide and aluminum chloride. In bromobenzene, the benzene can be described as deactivating and ortho, para-directing substituent. Yet , this response gives largely the para-isomer, presumably ortho-substitution which might end up being expected is definitely sterically less favoured. Device
Anhydrous aluminum chloride
pH indicator conventional paper
Bromobenzene and benzoyl chloride are put in a 40 mL Erlenmeyer flask. Aluminum chloride is added in three parts, shaking and stirring among additions. The flask can then be heated on a boiling water bathtub for 20 minutes. After 20 minutes, it is left cooled. The dark red water is poured onto an ice plus the remaining material are beaten up by...